Humalog and Novolog Novalog are both insulins used in the treatment of diabetes. But what are the differences and similarities between them? Medically reviewed by Drugs. Humalog and Novolog are both rapid acting forms of insulin that work for short periods of time; however, Humalog is approved in adults and children over the age of 3, but Novolog is approved for use in children as young as 2. Both are analogs of human insulin and effects in people with diabetes appear identical.
Costs and administration recommendations are similar. Humalog is a brand name for insulin lispro. Humalog starts to work about 15 minutes after injection, peaks in about 1 hour, and keeps working for 2 to 4 hours. Novolog is a brand name for insulin aspart.
NovoLog starts to work about 15 minutes after injection, peaks in about 1 hour, and keeps working for 2 to 4 hours. Novolog is commonly misspelled as Novolog. Insulin lispro is human insulin that has been modified so that the amino acid proline has been substituted for lysine in position 28 of the B-chain, and lysine has been substituted for proline at position 29 of the B-chain.
Insulin Aspart is human insulin that has a single substitution of proline for aspartic acid in position 28 of the B-chain. These seemingly minor substitutions significantly increase the rate of absorption of these insulin analogs into blood after subcutaneous injection.
Peak concentrations are reached quicker than with regular human insulin, postprandial glucose control level of blood sugars after a meal is also improved, and there is less risk of late hypoglycemia low blood sugar. One small study concluded that there were no differences between Insulin lispro Humalog and Insulin Aspart Novolog in people with type 1 diabetes.
Insulin levels in blood were similar 30 minutes after subcutaneous injection of either Lispro or Aspart and both disappeared from the blood after approximately 4 hours. Similar effects were also reported for glucose, carbohydrate, and fat metabolism. The study concluded that the clinical effects of Insulin Lispro and Insulin Aspart were indistinguishable from each other.
Dosing instructions supplied by the manufacturer do differ slightly. The manufacturers of Humalog suggest administration within 15 minutes of a meal or immediately after a meal, while the manufacturers of Novolog suggest administration 5 to 10 minutes before a meal or soon after the start of the meal. Humalog is used to treat type 1 diabetes in adults and children who are at least 3 years old, and can also be used to treat type 2 diabetes in adults.Humalog is a brand-name prescription medication.
Humalog and Humalog Mix are approved for use in adults with type 1 or type 2 diabetes. Humalog is also approved for use in children ages 3 years and older with type 1 diabetes. Humalog contains insulin lispro, which is a rapid-acting insulin analog. An analog is a man-made version of the natural insulin that your body makes. Humalog Mix contains a premixed combination of insulin lispro and a longer-acting insulin called insulin lispro protamine. This is an injection given directly under the skin.
Humalog can also be given as an intravenous injection by a healthcare provider. This is an injection into a vein. Both are suspensions a type of mixture in liquid that come in these forms:. A generic drug is an exact copy of the active drug in a brand-name medication. The generic is considered to be as safe and effective as the original drug. Generics tend to cost less than brand-name drugs. In some cases, the brand-name drug and the generic version may come in different forms and strengths.
A follow-on drug is very similar to the parent biologic drug. Follow-on drugs are used to treat the same conditions as the parent drug. Humalog is the parent drug of Admelog. Humalog is a biologic, so it would typically have just a follow-on version. For more information on insulin as a generic or follow-on, see the American Diabetes Association explanation.
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Humalog insulin is an insulin analog a man-made version of the natural insulin that your body makes.Continuing Education. Please enter valid email address. Login Register. Update Profile Logout.
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Humalog (insulin lispro)
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Basically, nothing. Humalog and Novolog are both synthetic, fast-acting forms of insulin that start working within 15 minutes but do not have long-lasting effects. They are usually paired with insulin that lasts longer such as intermediate or long-acting insulins. Humalog can be used and is approved in adults and children over the age of 3, but Novolog is approved for children two-years of age.
Both are analogs of human insulin, and effects in people with diabetes appear identical. The cost and administration recommendations are similar. Humalog and Novolog are used in people who have volatile glucose fluctuations, especially with meals. Humalog and Novolog are types of human insulin. Lispro insulin is known as the brand Humalog and starts to work about 15 minutes after injection, reaches a peak in about 1 hour, and keeps working for 2 to 4 hours.
Aspart insulin is also known as the brand NovoLog and also starts to work about 15 minutes after injection but can be earlier, peaks in about 1 hour, and continues to work for 2 to 4 hours. Both are prescribed with long-acting or intermediate-acting insulins. Humalog vs.
Insulin consists of two polypeptide multiple proteins chains A and B that are linked together by special chemical bonds called disulfide bonds. In the case of Humalog, this human insulin has been modified by substituting proline an amino acid for lysine in the 28th position on the B-chain while lysine is substituted for proline at position 29, also on the B-chain.
Novolog is human insulin that substitutes one position of proline for aspartic acid in position 28 of the B-chain. The purpose of these substitutions is to increase the absorption through the subcutaneous tissue to reach the blood faster compared to regular insulin.
This helps regulate glucose levels right after meals yet lowers the risk that the glucose drops too low, causing hypoglycemia. Onset of Action and Clearance of Humalog vs.Below is the formulary status of the 10 most common provider plans in your area by lives covered. Patients using a mail order pharmacy can still use this savings offer if they activate a co-pay card and submit for a rebate up to the maximum savings limit.
See more at PatientRebateOnline. GoodRx is a widely used prescription savings program. This is for example purposes only. Different websites and pharmacies will have different pricing. Pricing is subject to change, so be sure to visit prescription savings program websites to find the latest pricing options. The Insulins Val you Savings Program applies to the cost of medication.
There are other relevant costs associated with overall treatment. The products listed are not therapeutically equivalent and are not interchangeable. If your patients need additional financial assistance, click here. Learn about Savings Offers on other Sanofi Insulins.
Plan Name show all plans show all plans. Please check directly with the health plan to confirm coverage. Database current as of July All rights reserved. Preferred 2. Covered 4. If you or your office needs additional information, call 8 AM — 8 PM ET M-F except holidays Patients using a mail order pharmacy can still use this savings offer if they activate a co-pay card and submit for a rebate up to the maximum savings limit.
See how Insulins Val you Savings Program compares. Highly Similar to Humalog In structure and pharmacology 1,2. Resources Available Download clinical publications and resources for patients and pharmacists.Please mind - every topic is an article of its own.
For more related articles please hover over a topic and further subtopics to explore everything that Diabetes Daily has to offer. An insulin-to-carb ratio allows you to easily figure out how much of your fast-acting insulin is needed for the amount of carbohydrate you consume. An example of an insulin-to-carb ratio is meaning one unit of insulin is needed for every 15 grams of carbohydrate. Someone needing more insulin may have a ratio of and someone needing less insulin may have a ratio of When you are trying to figure out your correct ratio, it is helpful to write down your blood sugar levels and check more frequently to see how the insulin-to-carb ratio you used affected your blood sugar levels two hours after eating.
When an insulin-to-carb ratio works consistently well, keep it! But remember that factors like illness, skipping a meal, extra exercise, stress and other changes in routine may cause your insulin-to-carb ratio to change. This applies to people with type 1 diabetes who are taking multiple daily injections of insulin.
Humalog vs Novolog (Novalog): What's the difference?
They write :. If Humalog is used everyday to correct high readings, this may also need to be factored into the TDD. For others, such as those who use two injections a day with the morning basal insulin covering carbs at lunch, the Rule works only as a rough guide for matching carbohydrate.
Your body is often more resistant to insulin during different parts of the day or month.
For women in the week before menstruationinsulin-to-carb ratios may be adjusted each month to cope with these hormone changes and their effects on blood sugar levels. The key is to find a ratio that works well for you. For example, if you plan to eat 45 grams of carbohydrate and your insulin-to-carb ratio is 1 unit of insulin for every 15 grams of carbohydrate eaten, you would divide 45 by 15 to arrive at 3 units of insulin to cover that carbohydrate content.
The Diabetes Care of Nova Scotia provides a more complicated example:. If you count 72 grams of carbohydrate and your insulin-to-carb ratio is then you need to divide 72 grams of carbohydrate by This gives you 4. If you take injections, you might choose to round the 4.
It is important to understand how specific amounts of carbohydrates affect our individual blood sugar levels and work with your healthcare provider to determine the most appropriate insulin-to-carb ratio s for you. Also, keep in mind that although carbohydrates are the main dietary determinants of blood glucose fluctuation, other macronutrients like proteincan also affect blood glucose levels and may require and insulin dose.
What Is Diabetes?Forgot your password? Or sign in with one of these services. Nurse2bnwbie has 1 years experience. I have asked this same question many times to my coworkers but there is never a straight answer. They are concerned about the pt having a hypoglycemic episode overnight since the novolog acts faster, and many times the pt doesn't want to eat something that late at night, so what I have observed by far is the levemir being given but not the corrective dose of novolog for BS in the range of 's 's.
I will also appreciate if someone can address the issue of NPO pt and insulin It depends whether the sliding scale is calibrated to just drop the blood sugar to normal or to drop the blood sugar to normal and account for them eating.
The ideal situation is to have the sliding scale just drop the blood sugar to normal then st meal times give an additional amount of the rapid acting to cover the meal. In that case, it makes sense to correct a high blood sugar any time a glucose reading it taken, so long as insulin isn't being stacked additional insulin being given while a previous dose hasn't worn off yet.
Lantus is a basal insulin that has nothing at all to do with mealtime or ss insulin. If a BG is orthe Lantus does remains the same.
The SS amount would be given per order. IF blood sugar is higher than goal, sliding scale insulin is then used as a correction. Insulin requirements are dependent upon the patient and I don't see how it is weight related. In my case, I am on a very high dose of Lantus units daily due to inhaled and systemic corticosteroids. I split the dose. I also take Humalog before meals and at bedtime as needed. I am curious where weight comes into this? The only time my weight has come into it was when I was in DKA and was an insulin drip.
I typically don' take a prandial dose unless I am in the hospital and taking high doses of steroids. Again, the doses are not weight based. If you have a new diabetic you would dose the insulin based on weight.
So, a total daily dose, divided into a long acting and three meal time doses. Our insulin orders have low, med and high dose protocols that the docs choose from, so people that are more resistant to insulin get the high dose protocol. Once we get a few days on a consistent protocol then we can start titrating more specifically to individual patients.
These are patients that we need to start from scratch with, new diagnosis, or terrible compliance with no baseline. Once people get into the hospital their eating habits can be drastically changed too, and they get hypoglycemic on their home insulin doses.